The UC San Diego Materials Research Science and Engineering Center (MRSEC) explores new frontiers in (1) Quantum Metamaterials and (2) Chemically Tailored Superlattices. The Center leverages interdisciplinary expertise and capabilities that stem from two areas of historic strength on campus: metamaterials and two-dimensional superlattices. The fundamental research within the two interdisciplinary research groups (IRGs) is empowered by an integrated educational approach that connects training in laboratory procedures, advanced instrumentation, and state-of-the-art computational methods with industrial/national laboratory collaborations under an interdisciplinary umbrella. We exploit synergies with the NSF-supported Partnerships for Research and Education in Materials (PREM) and UC San Diego's Institute for Materials Design and Discovery.