The UC San Diego Materials Research Science and Engineering Center (UCSD MRSEC) explores new frontiers in (1) predictive assembly and (2) genetically programmed composite materials by harnessing the latest computational, nanotechnological, and biological tools. The Center leverages interdisciplinary expertise and capabilities that are uniquely available at UC San Diego—in particular, the world-leading expertise in biosystems engineering and in materials computation. The fundamental research within the two interdisciplinary research groups (IRGs) is empowered by an integrated educational approach that connects training in laboratory procedures, advanced instrumentation, and state-of-the-art computational methods with industrial/national laboratory collaborations under an interdisciplinary umbrella. We exploit synergies with the NSF-supported San Diego Nanotechnology Infrastructure and UC San Diego’s Institute for Materials Design and Discovery.